Japan has launched a five-year, $2 billion initiative to develop the
capacity to be able to create a vaccine within 100 days from the start
of a future pandemic.
That is, when a possible plague is detected and its genome is
sequenced, Japan will be able to produce vaccines three months later.
.https://www.nature.com/articles/d41586-022-03000-3
Japan’s $2-billion initiative to prep pandemic vaccines in 100 days
A new centre will invest in shots for a range of infectious diseases so the country is ready for future outbreaks.
After
recognizing that Japan was slow to develop vaccines for COVID-19, the
government has pledged to invest US$2 billion in a vaccine-research
initiative to ensure that the country is ready to respond promptly to
future epidemics.
The Strategic Center of Biomedical Advanced
Vaccine Research and Development for Preparedness and Response (SCARDA)
will initially invest in vaccine research for eight pathogens, including
coronaviruses, monkeypox, dengue virus and Zika virus, using a range of
technologies for vaccine delivery, such as mRNA technology, viral
vectors and recombinant proteins.
In recognition of this delay, the Japanese government established SCARDA in March; the centre will launch formally in November,
says Ishii. The government has realized that developing vaccines is
complicated and takes resources, and has given the field a boost, says
Toshihiro Horii, a vaccinologist at Osaka University. “That is a
tremendously huge amount of money,” he says.
Japan’s initiative is modeled after Western programs.
Hundred-day goal
SCARDA’s
aim will be to produce diagnostic tests, treatments and vaccines ready
for large-scale production within the first 100 days of a pathogen with
pandemic potential being identified. This 100-day mission was first
proposed by the United Kingdom in 2021, and backed by the other
countries in the G7 group of wealthy nations. Similar initiatives
include the US Biomedical Advanced Research and Development Agency
(BARDA); this coordinates the development of vaccines, drugs and
diagnostics in response to public-health emergencies, including
pandemics, and invested in several COVID-19 vaccines.
“Since
SCARDA is a new organization, it has much to learn from BARDA,” and
other initiatives funding vaccines such as the Coalition for Epidemic
Preparedness Innovations, says Michinari Hamaguchi, director general of
SCARDA.
Two particular programs within this initiative are notable:
- The development of universal coronavirus vaccine that people
would take once a year for protection against any and all coronaviruses.
- The development of vaccines for more specific coronaviruses related to SARS diseases.
Two of SCARDA’s first
approved projects aim to develop universal coronavirus vaccines and
vaccines against a group of coronaviruses related to severe acute
respiratory syndrome (SARS), such as SARS-CoV-2. Another project will create a fast-track system for evaluating vaccine candidates.
Japan’s centre will operate with around 30 members of staff and funding to last 5 years.
Of the allotted $2 billion, $1.2 billion will go to vaccine research
and development projects, and $400 million will be used to support
start-ups in drug development. Another $400 million will be spent on
setting up a virtual network of centres of excellence for basic research
in vaccine science, and testing vaccine candidates in early-stage
trials. The goal is “to find seeds for future vaccines”, says Kawaoka.
In
addition to the central research centre based in Tokyo, there will be
four core institutes — Osaka University, Nagasaki University, Hokkaido
University and Chiba University. Another five institutions will provide
support services such as animal models.
The Japanese initiative is modeled after the Western initiatives, but
the article does not mention to what degree there is cooperation or
redundancy between them.
One of the motives of the initiative might be the technological spin offs that might result from any scientific breakthrough.
For example, the mRNA vaccines are applicable to the treatment of cancer.
An analogy might be the New Zealand government’s subsidies to its
film industry, which also benefits New Zealand’s software industry and
its tourism industry.
A more focused effort is to develop a “universal” vaccine that would
apply to any and all possible mutations of the Covid-19 virus
(SARS-CoV-2).
Such a vaccine might be available in 2024.
As narrow as this ambition might seem because it focuses only on the
Covid virus, historically, it would be an unprecedented achievement.
.https://www.bbc.com/future/article/20220815-the-hunt-for-a-universal-covid-19-jab
[A] challenge that has long
proved insurmountable for scientists [is] to develop vaccines that can
not only protect against a single coronavirus, but multiple strains,
varieties, and perhaps even entire families of them. A comparable feat
has never been managed in the history of virology, after more than two
decades of chasing the same goal in influenza yielded little of note.
Some have even compared the task’s ambition, scope and difficulty to the
infamous Manhattan Project of the 1940s, which pushed the boundaries of
physics at the time, and yielded the world’s first atomic bomb.
Money is being thrown at the target in unprecedented sums. CEPI have allocated an initial budget of around $200m (£169m/€193m), with the NIH adding an additional $36m (£30m/€35m) to
the pot. Buoyed by their success in developing one of the first
Covid-19 vaccines, Moderna has recently entered the fray, announcing
their intention to produce a vaccine which could protect against all
four coronaviruses that cause the common cold.
Heeney
knows the road ahead better than anyone, having also spent the last few
years attempting to develop a single vaccine that can protect against
different viral haemorrhagic fevers – Ebola, Marburg virus and Lassa
fever.
The ultimate goal is to develop a universal vaccine that would protect against all forms of coronaviruses.
However, this will not be achieved until further off in the future.
Developing vaccines that would protect against variants of Covid is
therefore a steppingstone to the greater goal of creating a vaccine that
would apply to all coronaviruses.
All scientists agree that a
truly universal vaccine, which could protect against every single
coronavirus that might emerge in future, would be a genuinely
game-changing moment for human health, especially in the wake of the
devastation caused by the Sars, Mers and Sars-CoV-2 (the virus that
causes Covid-19) outbreaks of the last 20 years.
But
while this would be the pinnacle of pan-coronavirus vaccine research, it
remains to be seen whether it can actually be achieved. Instead some
feel that various intermediate targets are more realistic, before
scientists consider expanding the remit of these jabs.
As
a result, the first step towards a possible universal coronavirus
vaccine is likely to be a so-called “variant-proof” vaccine, which aims
to protect against all current and future strains of Sars-CoV-2 and help
end the worst impacts of the pandemic. With the continuing emergence of
problematic variants causing repeated surges in case numbers and
hospitalisations, beginning with Alpha in September 2020, to Delta,
Omicron, and now BA.4 and BA.5, the need for such a vaccine remains
high.All sorts of vaccine technologies are being explored.
In
order to do this, scientists are trialling a kaleidoscope of vaccine
technologies. They range from modified, harmless viruses known as
adenoviruses to ferritin nanoparticles and self-amplifying RNA, which
works in a similar fashion to messenger RNA (mRNA) except it can copy
itself once inside the body’s cells, meaning much smaller doses are
needed.
In each case, the general idea is more or less
the same. Whether carried by a nanoparticle or an adenovirus, each
vaccine contains a variety of different fragments of the Sars-CoV-2
virus’ spike proteins (which the virus uses to bind to human cells to
gain access), and nucleocapsid proteins (which store its genetic
material). Some vaccine-makers are looking to incorporate as many
fragments as possible to increase the chances of having a broader immune
response, while others are focusing on specific parts of the virus that
seem to be conserved across each of the strains that have emerged so
far. At Duke University, virologists are targeting a particular part of
the spike protein known as the receptor binding domain (RBD), as this
region appears to have relatively little variation between different
forms of the same coronavirus.
Because of the increased
complexity of the challenge, progress will be slower compared to the
first wave of Covid-19 vaccines. None of the variant-proof vaccines in
development have progressed beyond phase I clinical trials (the first
test in humans), but the initial data appears to be promising.
Some scientists, however, are looking to develop universal vaccines that take aim at less notorious viruses.
For example, sometimes when we catch a cold, we say that we have a case of the “flu”.
However, many of those cases of the “flu” are not actually caused by influenza viruses.
In fact, some of those inconvenient colds that knock us out for a couple of days are caused by obscure coronaviruses.
Tackling the common cold
Rather
than entering the competitive landscape of Covid-19 vaccines, other
researchers have decided to look at different forms of pan-coronavirus
vaccines.
These are OC43, HKU1, 229E, and NL63, not
household names, but the majority of us will have unknowingly
encountered them at some point in our lives. They are responsible for around 30% of
common colds in adults, and while these viruses have nowhere near the
fatality rate of Sars-CoV-2, they can still lead to lower respiratory
tract infections and pneumonia in the vulnerable.
There is also an effort to develop a vaccine that would protect against SARS-related coronaviruses.
This
in itself is already an ambitious goal, attempting to vaccinate against
a group of different coronaviruses, but other scientists are setting
the bar even higher. Rather than designing vaccines against existing
viruses, they want to initiate humanity’s preparations for the next
pandemic.
Pamela Bjorkman, a professor of biology and
biological engineering at the California Institute of Technology, is
leading a project to develop a jab which can immunise against any
sarbecoronavirus – severe acute respiratory syndrome–related coronavirus
– a collective which includes Sars, Mers, Sars-CoV-2 as well as other
as-yet-unknown threats harboured within animals. Heeney’s team is
targeting an even larger viral cluster – the entire group of
betacoronaviruses, one of four groups of coronaviruses which includes
the sarbecoronavirus sub-group.
While a
pan-betacoronavirus jab would still not come close to being a universal
coronavirus vaccine – it would still leave the other three groups of
coronaviruses, alpha, delta and gamma, untargeted – it is still an
incredibly challenging goal. To illustrate the sheer scale of the task,
there are thought to be thousands of as-yet undiscovered
betacoronaviruses residing within more than 400 different bat species.
Universal vaccines for coronaviruses might be more feasible than
universal vaccines for influenza viruses because coronaviruses mutate at
a slower rate.
The big question for all
pan-coronavirus vaccine developers is whether they can succeed where
pan-influenza vaccines have failed. The NIH’s National Institute of
Allergy and Infectious Diseases unit has an annual budget of
approximately $220m (£180m/€212m) for universal flu vaccine research but
progress has been minimal despite decades of striving. However, there
is hope that the challenge may be slightly less complex in coronaviruses
because in general, they are not so prone to mutating.
Scientists
are hopeful that the first variant-proof Covid-19 vaccines will be
available by 2024, potentially ushering in a wave of coronavirus jabs
offering increasingly broad protection. For many, this would be up there
with some of the most important breakthroughs in modern healthcare.
.
The bigger question is how many people will get vaccinated if universal vaccines are developed?
For example, as of late 2022 with regard to the Covid vaccines:
- 20% of Americans have not been vaccinated even once,
- one-third of Americans have not gotten a second dose of vaccine, and
- two-thirds of Americans have not gotten their third dose.
Hundreds of Americans are dying each day from Covid, and it is primarily because they have not been adequately vaccinated.
Dr. Anthony Fauci noted that with the availability of safe and
effective vaccines, there is no reason why ANYONE should be dying of
Covid.
Who should get the new boosters, and when?
.https://www.cdc.gov/coronavirus/2019-ncov/vaccines/stay-up-to-date.html
CDC recommends that people ages 12 years and older receive one
updated (bivalent) booster if it has been at least 2 months since their
last COVID-19 vaccine dose, whether that was:
- Their final primary series dose, or
- An original (monovalent) booster
People who have had more than one original (monovalent) booster are also recommended to get an updated (bivalent) booster.
The new boosters are called “bivalent” because they prepare the body
to fight for both the original strain of Covid as well as the new
variants.
This offers protection from many variants, because when the immune
system faces different versions of the same virus it generates broader
protections overall.
A booster with the new vaccines decrease the likelihood of infection
and severe illness and help reduce transmission of the virus.
It could also decrease the likelihood of developing long Covid.
Also, despite common claims to the contrary, vaccines still
help dampen spread, and boosters can further reduce transmission of the
disease.
This includes reducing infections in the first place, and thus help protect especially the more vulnerable.
Even when variants cause breakthroughs, vaccines still prevent serious illness and death, and even more so with boosters.
However, for various reasons, Americans are not getting the new boosters.
.https://www.nytimes.com/2022/09/15/opinion/covid-booster-shot.html
.
How often will people be reinfected with Covid?
There were almost no reinfections during the first year of Covid in 2020.
However, since the arrival of variants, everybody is experiencing reinfection.
.https://www.newyorker.com/science/annals-of-medicine/how-many-times-will-you-get-covid
During the first year of the
pandemic, when reports of coronavirus reinfections started to trickle
in, the phenomenon was considered exceedingly rare—“a microliter-sized
drop in the bucket,” as one virologist put it. As of October, 2020, the
world had recorded thirty-eight million coronavirus cases and fewer than
five confirmed reinfections. Two years later, the bucket is
overflowing. It’s now clear that not only will just about everyone
contract the coronavirus, but we’re all likely to be infected multiple
times. The virus evolves too efficiently, our immunity wanes too
quickly, and, although covid vaccines have proved remarkably durable
against serious illness, they haven’t managed to break the chain of
transmission.
Rational people now fear Covid not for the death that it might have
caused prior to the vaccines but because reinfection may cause them
long-term harm.
The so-called “endemic stage” that was promised turns out to be
rougher and somewhat more dangerous than what we had anticipated.
On the whole, however, things are continuing to improve on the Covid
front with each new round of vaccinations — and reinfections — as humans
slowly build their immunity to Covid.
In the U.S., covid is still on
pace to kill more than a hundred thousand people per year; many of us
share the reasonable worry that some future reinfection will be the one
that causes longer-term harm to our health and quality of life. Has our
battle with covid-19 come to such a standstill that a slow burn of
disruption, debility, and death will continue for years to come?
The
specialists I consulted for this story shared a conviction that,
despite the relentlessness of reinfections, our covid woes are slowly
starting to recede. They said that, although coronavirus infections will
always carry risks, and we may still suffer periodic surges and new
variants, infections should get less serious and less frequent as our
immunity grows. Vaccines and therapeutics will also continue to improve,
helping to lessen the worst effects of reinfection. But the duration
and severity of this transitional period matters, too. How many times
will we have to sit through quarantines and ride out symptoms, worrying
how bad this one might be? How many more surprises could the coronavirus
have in store?
The rate of reinfection has increased with each new variant.
The reinfection era began in earnest last winter, when the Omicron variant first spread around the globe. A recent study conducted
in Serbia found that for people who were infected in the first twenty
months of the pandemic, the risk of reinfection rose steadily but
slowly: at six months, around one in a hundred had been reinfected; at
twelve months, one in twenty; and at eighteen months, one in five. But
Omicron sent reinfections skyrocketing. Nearly ninety per cent of all
reinfections occurred in the study’s final month, January, 2022. (The
researchers found that one in a hundred reinfections led to
hospitalization, and one in a thousand resulted in death.) By some estimates, the initial Omicron outbreak caused ten times as many reinfections as the earlier Delta variant. And Omicron now circulates in the form of even more contagious subvariants, such as BA.4 and BA.5.
However, reinfection is inconsequential as long as our immunity to
Covid has not faded, if our system still recognizes a mutated virus, and
if exposure is only to small amounts of virus.
Fundamentally, our risk of reinfections depends on three main factors:
- how much our immunity has waned,
- how much the virus has changed, and
- how much of it we encounter.
Our collective immunity
increases with infections, reinfections, and vaccines. Booster shots are
meant to slow the drawdowns in our immunity, and the recently approved
bivalent vaccines, which target the Omicron subvariants BA.4 and BA.5,
may be particularly helpful. But the immune system must be judicious: it
encounters countless threats and can’t maintain enormous standing
armies for each one. Over time, our bodies pare back their defenses, and
whether we’re reinfected depends partly on how quickly and intensely
they remobilize during the next encounter.
Our immune
protections also exert pressure on the virus to evolve around them.
Viruses can change so much that the body has trouble recognizing and
subduing them. The original Omicron variant had at least thirty-two
mutations on its spike protein—twice as many as Delta—and, in recent
months, its subvariants have accumulated many more. sars-CoV-2 is
mutating faster than any of its cousin coronaviruses—faster, even, than
the world’s dominant flu strain.
Finally, the chance
you’re reinfected is a function of “viral dose.” It’s more than just a
numbers game: our immune cells have to be stationed in the right places.
“It’s like real estate in Manhattan,” Florian Krammer, a virologist at
Mount Sinai’s Medical School, told me. “Location really
matters.” covid vaccines injected into muscle produce relatively high
levels of antibodies in the blood and lungs, but not in the nose, mouth,
and upper airways, where the coronavirus usually enters. (Natural
infection seems to produce a longer-lasting immune response in the nasal
cavity.) That’s why scientists are so interested in mucosal vaccines,
which are administered in the nose or mouth. India and China recently
authorized such vaccines, but it’s still not clear how effective they’ll
be.
There are four other types of coronaviruses other than the Covid virus that afflict humans
However, they cause only cold symptoms because the human immune system knows how to deal with them.
This familiarity also reduces the frequency of infection because the immune system has learned how to block the virus from reproducing even a little in the body.
Thus, these viruses tend to reinfect humans only every three years, either with or without symptoms.
Humans are now gradually developing an immunity to Covid.
Within five years or sooner, humanity might reach a point where we will only be reinfected with Covid once every five years.
But that would still mean that many of us could get Covid ten times or more in our lifetimes.
Importantly, reinfection might still be a big problem — for some people.
People who are reinfected by
the virus are much more likely to suffer a range of medical problems in
subsequent months, including heart attacks, strokes, breathing problems,
mental-health problems, and kidney disorders, according to a major new analysis of U.S. veterans.
There
are some caveats. The study has not yet been published in a
peer-reviewed journal, and many veterans are older men with multiple
medical conditions, so they have a higher level of risk than the general
population. It’s also possible that people who get reinfected are
somehow dissimilar from those who don’t. Al-Aly was careful to note that
a second infection isn’t necessarily worse than a first one—rather,
that it’s worse than not getting reinfected at all.
The bad news is that getting reinfected with Covid might remain risky.
The “good” news is that people die all the time from viruses, but
with Covid vaccines and reinfections the deaths won’t be as overwhelming
as they were in 2020.
Recently, I called Florian
Krammer, the Mount Sinai virologist, and outlined a pessimistic
scenario: a future in which covid reinfections are common, dangerous,
and inevitable. “When you say it like that, it sounds very bad,” Krammer
admitted. “But I actually don’t see it that way.” There’s nothing
special about the coronavirus, he argued. Yes, sars-CoV-2 caused a
global pandemic, but he thinks that was primarily because of its
novelty. We perceive the virus as unique because we’re so focussed on
it—it’s one of the most closely studied pathogens in human history—but
it obeys the same general rules as other viruses.
Viruses
have always caused a variety of immediate and lasting health problems.
It’s just that “most people haven’t been paying attention,” Krammer
said. Long before this pandemic, for example, viral infections were
linked to diabetes, cancer, heart problems, and autoimmune
conditions. Five years ago, in her book on the 1918 influenza pandemic,
the journalist Laura Spinney wrote about people who suffered prolonged weakness, fatigue, brain fog, insomnia, and mood changes.
In
parts of Africa, post-viral syndromes were so widespread among farmers
that they’re thought to have triggered a famine.
Recent research suggests that even non-pandemic influenza may be
associated with protracted symptoms: according to researchers at Oxford,
nearly a third of people who contract the flu virus today report
symptoms that resemble long covid, and could be suffering what might be
called “long flu.”
“In the long run, sars-CoV-2 will be just another respiratory virus,” Krammer predicted.
Al-Aly
was less sanguine. He sees little reason that covid risks will
necessarily drop to the level of influenza, and, in any case, we’re not
there yet. “We have to balance the need for normalcy with the need to
protect the health of the people,” he said. Still, he agreed with
Krammer and the other experts on one thing: the added burden of a third,
fourth, or fifth infection will probably be lower than the first or
second. Each new infection may come with diminishing marginal pains.
“There will come a point where reinfection will not add more risk,”
Al-Aly said. “Whether that is the sixth or seventh or nth infection, we
don’t know yet.”
.
Vaccine hesitancy might be as greater in parts of the developing world than in the USA.
In the developing world, however, vaccine hesitancy might not
primarily be based on political polarization or lessened social cohesion
and loss of social trust.
In fact, quite the opposite, if the case of New Caledonia is any indication.
The source of vaccine hesitancy in the developing world might be traditions that underpin social cohesion.
From a March, 2022 New York Times story:
.https://www.nytimes.com/2022/03/12/world/australia/new-caledonia-coronavirus.html
On Pacific Islands Covid Once Spared, an Outbreak Accentuates Inequality
New
Caledonia escaped the coronavirus for a year and a half, but a surge in
cases has led to a state of emergency, with the disease
disproportionately hurting the French territory’s Indigenous people.
Historically, people in New Caledonia have responded to pandemics by sealing their borders for years.
With a locally sourced complete diet and an economy based on
subsistence, this is not the kind of challenge it would pose to a
globally integrated modern society.
Unfortunately, the habits of the people have not caught up to the reality of living in a modern France administered from Paris.
With the introduction of vaccines, New Caledonia was opened to travel
— but the New Caledonians largely failed to get vaccinated.
They were hit hard by the Delta variant.
NOUMÉA, New Caledonia —
Festooned with hibiscus flowers and woven palm fronds, scores of guests
gathered for a celebration during New Caledonia’s wedding season. The
aroma of grilled fish and yams bathed in coconut milk wafted over the
revelers on the island of Lifou, population 10,000.
The
celebration on the atoll in late August seemed safe. For a year and a
half, New Caledonia, a French territory in the South Pacific, had
escaped the coronavirus pandemic. Quarantines and border controls kept
the virus out, just like they had done during the worst of the influenza
pandemic a century earlier.
But by mid-September, the
Delta variant was racing across New Caledonia, home to about 270,000
people. Of the nearly 13,300 people who tested positive within the span
of a few weeks, more than 280 people died, a higher mortality rate than
what the United States or France experienced last year.
The Omicron variant has been more merciful than the Delta, but vaccination rates remain relatively low in New Caledonia.
Of all the South Pacific
islands recently struggling with outbreaks, New Caledonia was among the
most inundated, prompting the government to declare a state of emergency
earlier this year. Less than 70 percent of the population has been
fully vaccinated, despite plentiful supplies. (Few people here have died
from Omicron, compared with Delta, and the surge has eased in recent
days.)
Local vaccine resistance might at first seem libertarian — but the mentality is really traditionalistic and communal.
A protest encampment on a
coastal road in Nouméa, the capital, is decorated with hand-scrawled
signs declaring “non” to vaccine mandates and health passes.
Serious
coronavirus infections have disproportionately affected New Caledonians
of Pacific Island descent, highlighting social inequalities in a
territory that is agonizing over whether to break free of France.
What some observers often do not notice is that indigenous peoples
tend to be ultraconservative and their lives are governed by tradition,
religion, and ritual.
An independence referendum in
December failed in part because many Indigenous Kanaks, who make up
about 40 percent of the population, boycotted the vote. They had called
for a delay because traditional mourning rituals for those who died of
Covid precluded political campaigning. (After so many deaths from
Delta, some New Caledonians have been consumed by the Kanak rituals of
grief, which unfold over a year.) Paris, unmoved, forged ahead with the referendum.
The habits of American journalists might be to perceive indigenous
peoples as victims of “inequality”, but this sort of analysis might be
compromised.
In fact, the indigenous people of New Caledonia have some of the best medical facilities in all of France.
New Caledonia’s health system
benefits from the largess of the French state, which heavily subsidizes
the territory. Critically ill Covid patients are warded in a
state-of-the-art intensive care unit at the Médipôle Hospital near
Nouméa, far fancier than many facilities in France. When cases spiked
last year, about 300 medical professionals converged on New Caledonia,
coming from France and its overseas territories.
But the
strong social safety net hasn’t bridged the divide between New
Caledonia’s population of Indigenous Oceanians and largely white
migrants. Eighty percent of doctors at Médipôle are from France,
hospital officials said. There are few Kanak doctors in all of New
Caledonia, and none at Médipôle.
The real problem in New Caledonia might be too much equality.
As equal citizens of a generous French state, the indigenous peoples have lost control of their borders and their way of life.
High levels of diabetes,
hypertension and obesity among people of South Pacific descent have
compounded New Caledonia’s Covid crisis, doctors said. The territory may
be one of the richest places in the South Pacific because of French
subsidies and mineral wealth, but the income gap is wide. Most of New
Caledonia’s impoverished people are Melanesian Kanaks and Polynesian
immigrants from a pinprick French territory called Wallis and Futuna.
European settlers, who make up about one-quarter of the population, tend
to occupy the upper wealth rungs.
As Frenchmen, New Caledonians are compelled to accept an unhealthy and alienating existence.
As more Kanaks move from
tribal villages to Nouméa, congregating in grim apartment blocks, they
leave behind gardens brimming with taro, yam and plentiful vegetables
and fruits.
But fresh produce is expensive in the
capital, with prices skewed by the high salaries given to employees of
the French state. In Nouméa, boulangeries selling croissants made with
imported French butter stand next to groceries offering wilted greens at
exorbitant prices. The cheapest fare is processed snacks and sugary
sodas.
“When I was a child, there were few fat people
here,” said Dr. Thierry de Greslan, 52, a neurologist at Médipôle. “But
our sedentary lifestyles and bad diet have created a terrible problem,
and that has made us very scared of Covid.”
When the French did attempt to be benevolent, it so often made things worse.
A scattering of islands strewn
north of New Zealand, New Caledonia has long seen its history shaped by
disease. Europeans arrived in the 19th century, bringing with them
pathogens and toxic notions of empire. The French colonial
administration herded Kanaks onto reservations and stole their land.
Diseases
like cholera and smallpox proliferated. A campaign to force Kanaks to
whitewash their homes led to high cancer rates from the asbestos in the
white clay. Three-quarters of a century after their first contact with
Europeans, the Kanak population had declined by about half.
One of the bright spots of New Caledonia’s history was their ability to restrict travel during the 1918 influenza pandemic.
The locals seem to have thought that the same policy of restricted
travel would remain in place until Covid largely disappeared from the
world.
Thus, so many indigenous New Caledonians did not get themselves vaccinated.
However, French courts determined that with the availability of Covid vaccines, the restrictions on travel were illegal.
But when the influenza
pandemic began racing around the world a century ago, New Caledonia was
one of the few places on the planet to emerge largely unscathed. A
strict quarantine kept the virus out until 1921, by which time its
virulence had diminished.
In January 2021, New Caledonia
was one of the world’s first places to receive ample coronavirus
vaccines. The territory had boosters available before much of France.
Yet when Delta hit, less than half of the population had been
vaccinated.
“There is a closed island mentality, so
people thought they were safe,” said Yannick Slamet, the health minister
of New Caledonia. “People forget history quickly.”
But
when the influenza pandemic began racing around the world a century ago,
New Caledonia was one of the few places on the planet to emerge largely
unscathed. A strict quarantine kept the virus out until 1921, by which
time its virulence had diminished.
In January 2021, New
Caledonia was one of the world’s first places to receive ample
coronavirus vaccines. The territory had boosters available before much
of France. Yet when Delta hit, less than half of the population had been
vaccinated.
“There is a closed island mentality, so
people thought they were safe,” said Yannick Slamet, the health minister
of New Caledonia. “People forget history quickly.”
Anti-vaccination rallies in New Caledonia are one of the few places
where the socially conservative native and the libertarian Frenchman
interact and agree.
Anti-vaccination rallies are
one of the few events in Nouméa that draw both Kanaks and white New
Caledonians in an otherwise often segregated society. At a demonstration
late last year in front of the New Caledonian Congress, with its wooden
totems standing guard, protesters set up speakers and danced to Bob
Marley. They hissed at onlookers wearing masks.
One Kanak
protester, a hospital worker, said she drew inspiration from QAnon. She
wanted to know how to get in touch with the far-right conspiracy
movement. Another, of European descent, said he didn’t want the state
dictating his life, even if he supported France continuing its rule over
New Caledonia.Last month, tribal leaders in Lifou, one of the first
Covid hot spots in New Caledonia, forced the airport to briefly close to
protest a rule requiring health passes or testing for travelers. In
January, an anti-vaccination and health pass mandate protest in Nouméa
attracted 1,000 people. Covid restrictions have since eased.
Again, if the issue of vaccine hesitancy is “inequality” as the New
York Times article asserts, it is not the inequality between the French
and the indigenous peoples that is causing it.
Vaccine hesitancy in the case of New Caledonia seems to be based on
the past reliance on border closures, and a traditionalist mind frame
that assumes that this policy still exist.
That seems distinct from the vaccine hesitancy of France’s population.
There is a subset of France’s population that violently opposes any government initiative.
This is the reaction against a highly centralized French state, and the persistence of the spirit of the French Revolution.
There is also the populist phenomenon of vaccine resistance that was explored during the Canadian trucking strike.
Truck driving was pointed out to be a classic isolated existence that
has become more isolated because of Covid restrictions and the decline
of labor unions.
The argument is that with the decline of civil society, people turn
toward conspiracy theories to simulate the feeling of being in an
embattled community.
In any case, it might be useful to glance at what territorial status
means in the French republic to better understand New Caledonia.
Overseas territories of France like New Caledonia that were once a part of France’s empire have varying statuses.
https://en.wikipedia.org/wiki/Overseas_France
Overseas France (French: France d’outre-mer)[note 3] consists of 13 French-administered territories outside Europe, mostly the remains of the French colonial empire that chose to remain a part of the French state under various statuses after decolonization. They are part of the European Union.
This collective name is used in everyday life in France but is not an
administrative designation in its own right. Instead, the five overseas regions have exactly the same administrative status as the metropolitan regions; the five overseas collectivities are semi-autonomous; and New Caledonia is an autonomous territory.
Outside Europe, four broad classes of overseas French territorial administration currently exist:
- overseas departments/regions,
- overseas collectivities,
- the sui generis territory of New Caledonia, and
- uninhabited territories.
From a legal and
administrative standpoint, these four classes have varying legal status
and levels of autonomy, although all permanently inhabited territories
have representation in both France’s National Assembly and Senate, which together make up the French Parliament.
On the face of it, New Caledonia’s political status as an autonomous
territory does not seem immediately comparable to any territory of the
USA.
In the USA, there seems to be a continuum of political integration that involves a tradeoff between power and autonomy.
- The 50 states of the USA enjoy political representation and, with it, power and financial patronage;
- territories like Puerto Rico do not pay federal taxes, but have only a non-voting representative in the US House; and
- territories that become independent nations have the greatest independence but are now on their own.
.
This leads us to a detour into re-imagining territorial status.
The thought-experiment here is to imagine a new kind of territorial entity that would enjoy the best of both worlds.
Such a territory would enjoin autonomy and zero federal taxes, but maintain political power and substantial federal investment.
The goal would be economic development and diversification to offset
the tendency for small, geographically isolated places to be
economically doomed.
The “problem” is that New Caledonia has something like this mix of
autonomy and generosity from the central government — but it largely
remains in a state of semi-development.
That seems to be the way people in New Caledonia want it to be so it is not really a problem in their eyes.
That might also be true of American territories.
For example, it’s been said that the typical dream of Puerto Ricans
is to live on a small farm next door to their parents’ small farm.
But a small farm in Puerto Rico is really small and pre-industrial, with the chickens and the goats and the gandules bean plants.
Not everybody wants a modern, dynamic economy.
But the larger thought-experiment behind re-imagining territorial
status is to figure out a way to make a country like Singapore apply to
be an American territory.
For example, the Soviet Union had a federal system that incorporated
over a dozen distinct nation-states in a “union of socialist republics”.
There were ideological and practical considerations behind this arrangement.
https://en.wikipedia.org/wiki/National_delimitation_in_the_Soviet_Union
Rationale
Russia had conquered Central Asia in the 19th century by annexing the formerly independent khanates of Kokand and Khiva and the Emirate of Bukhara. After the Communists took power in 1917 and created the Soviet Union it
was decided to divide Central Asia into ethnically based republics in a
process known as National Territorial Delimitation (NTD). This was in
line with Communist theory that nationalism was a necessary step on the
path towards an eventually communist society, and Joseph Stalin’s
definition of a nation as being “a historically constituted, stable
community of people, formed on the basis of a common language,
territory, economic life, and psychological make-up manifested in a
common culture”.
NTD is commonly portrayed as being nothing more than a cynical exercise in divide and rule,
a deliberately Machiavellian attempt by Stalin to maintain Soviet
hegemony over the region by artificially dividing its inhabitants into
separate nations and with borders deliberately drawn so as to leave
minorities within each state.[13] Though indeed Russia was concerned at the possible threat of pan-Turkic nationalism,[14] as expressed for example with the Basmachi movement of the 1920s, closer analysis informed by the primary sources paints a much more nuanced picture than is commonly presented.
NTD
also aimed to create ‘viable’ entities, with economic, geographical,
agricultural and infrastructural matters also to be taken into account
and frequently trumping those of ethnicity.[21][22] The
attempt to balance these contradictory aims within an overall
nationalist framework proved exceedingly difficult and often impossible,
resulting in the drawing of often tortuously convoluted borders,
multiple enclaves and the unavoidable creation of large minorities who
ended up living in the ‘wrong’ republic. Additionally the Soviets never
intended for these borders to become international frontiers.
There is one more possibility not mentioned above that explains this
willingness of Soviet leaders to recognize and respect non-Russian
political and ethnic identity (made visible in ostentatiously gifting
Russian land to other nationalities within the USSR).
This policy would facilitate the expansion of the USSR by reassuring
other nations that they could maintain their cultures and administrative
structures as members of the federation.
Drawing inspiration from the USSR, the idea here is that the USA
would develop an additional territorial status that would appeal to
small, prosperous countries like Singapore.
- Singaporeans would be able to freely travel to and work in the USA.
- Singaporeans would pay minimal US federal taxes.
- Singaporeans would have their own laws and complete political autonomy.
- Singapore would have voting representatives in the US House.
Singapore would be put under American protection, but otherwise Singapore would remain Singapore.
Moreover, something like this new territorial arrangement would be available to an independent Scotland, Quebec, or Texas.
With Texas as a territory of the USA, there would be no federal taxes
in Texas, the USA would handle Texas’s foreign policy, Texas would get
representation in the US House — but Texas would otherwise be an
independent country.